Georgia

IL-5 directly involves and affects several target cells, including eosinophils and B cells, inducing cell proliferation, survival and differentiation, making it a key factor in the inflammatory process in asthma, CRSwNP, EGPA and HES. Understanding this inflammatory phenomenon and its specific treatment options is essential for the management of patients and their comorbidities.
This webinar comprehensively address the full complexity of IL-5 and its mechanism of action.

Learning Objectives:

• To develop the concept of immune response and its mechanisms
• To put the focus in IL-5 as a modulator of response
• To understand the biological effects of IL-5 and the broader role beyond eosinophilic inflammation
• To link Type 2 inflammation with respiratory diseases To interpret the mechanism of action of biologics

LECTURE 1: What do we talk about when we talk about IL-5?

• Past and present of our knowledge about IL-5
• IL-5 as a modulator of our acquired immune response
• Eosinophils and Type 2 inflammation

LECTURE 2: IL-5: the multi-causal nexus

• Respiratory field – Asthma, and CRSwNP

LECTURE 3: IL-5: A Key Target in Type 2 Disease

• Understanding the mechanism of action
• Severe/refractory asthma – Putting the focus on decreasing the burden of the disease
• Severe/refractory CRSwNP
• IL-5 vs. IL-5R
• Future perspectives

In research, the highest quality data comes from randomized controlled trials. Despite being the gold standard, it is not always possible to apply them due to the resources and personnel required. In such cases, indirect treatment comparisons are a valid and widely accepted option for comparing evidence or interventions from different studies. This on-demand webinar aims to shed light on this methodology applied to the field of CRSwNP.

Learning Objectives:

• To develop the concept of levels of scientific evidence
• To learn about randomized controlled trials and their limitations
• To apply ITCs in research and compare it with other options
• To receive applied notions on ITCs in CRSwNP

LECTURE 1: Research

• Levels of scientific evidence – Is all the evidence good enough?
• Randomized controlled trials – Considering the limitations
• Step by step - ITC methodology

LECTURE 2: ITC in Research

• CT vs. control or placebo – Extrapolating conclusions
• ITC vs. DTC - How to control the bias factor?
• ITC vs. meta-analysis

LECTURE 3: ITC in CRSwNP

• The lack of head-to-head randomized clinical trials – What can be done?
• Inclusion criteria – What can be compared?
• Factors to consider to minimize the bias

Please complete the survey link at the bottom of the page to receive your EUFOREA certification of attendance of this educational programme.

Summary

Please complete the survey link at the bottom of the page to receive your EUFOREA certification of attendance of this educational programme.

Master Class series about biological treatment options in Asthma and CRSwNP.
Please complete the survey link at the bottom of the page to receive your CME certificate.